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41 days holiday
Per the ad, which doesn’t say whether bank holidays are on top.
Cycle to work and season ticket loan
Commuter benefits named in the ad.
As well as the exciting opportunities this role presents, we also offer some great benefits some of which are below: • 41 Days holiday (27 days annual leave 8 bank holiday and 6 closure days) • Additional 5 days' annual leave purchase scheme • Defined benefit career average revalued earnings pension scheme (CARE) • Cycle to work scheme and season ticket loan • Immigration loan • Relocation scheme for certain posts • On-Site nursery • On-site gym • Enhanced maternity, paternity and adoption pay • Employee assistance programme: Staff Support Service • Discounted medical insurance Visit https://www.ucl.ac.uk/work-at-ucl/reward-and-benefits to find out more.
We are seeking a highly motivated scientist who is enthusiastic about developing innovative therapies for children affected by rare neurological diseases. Candidates should have recently obtained, or be about to obtain, an MSc in Neuroscience, Molecular Biology, Biomedical Sciences or a closely related discipline. Experience with molecular biology techniques and rodent models is expected, together with strong skills in scientific communication, literature review and scientific writing. Previous hands-on experience in mRNA research and technology is essential.
This is an excellent opportunity to join a dynamic translational research programme and contribute to the development of a potentially transformative therapeutic approach for neuronopathic Gaucher disease. Post is available for 12 -14 Months.
A Research Assistant position is available in the laboratory of Professor Julien Baruteau at the Great Ormond Street Institute of Child Health. The successful candidate will join a GOSH Charity-funded project developing mRNA therapy for neuronopathic Gaucher disease, a severe and currently incurable form of Gaucher disease characterised by progressive neurological involvement. The project aims to develop a therapeutic mRNA approach capable of restoring glucocerebrosidase (GCase) activity in the brain and ultimately providing a new treatment strategy for patients with neuronopathic disease.
The project is already progressing well, with optimisation of the therapeutic mRNA construct underway and promising initial in vitro results. Over the course of the 12-15-month appointment, the post-holder will play a key role in advancing the programme towards in vivo proof-of-concept. Their responsibilities will include: • Completing the in vitro optimisation and characterisation of the therapeutic mRNA construct. • Investigating mRNA delivery to the mouse brain and evaluating expression and biodistribution. • Maintaining and managing a mouse model of neuronopathic Gaucher disease. • Performing in vivo studies to assess the therapeutic efficacy of the optimised mRNA construct. • Contributing to experimental design, data analysis, interpretation and dissemination of findings. The post-holder will benefit from close scientific interaction with Professor Ahad Rahim at the UCL School of Pharmacy and Professor Stephen Hart at UCL Great Ormond Street Institute of Child Health, providing an exciting multidisciplinary environment spanning RNA therapeutics, gene therapy, neuroscience and rare disease research.
The mission of the UCL GOS Institute of Child Health is to maximise and advocate for the holistic health of all children, young people and the adults they will become, through world-class research, education and public engagement. The UCL GOS ICH, together with its clinical partner Great Ormond Street Hospital for Children, forms the largest concentration of children's health research outside North America. The 2024-29 GOS ICH strategy focuses on its five scientific programmes. GOS ICH's activities include active engagement with children and families, to ensure that our work is relevant and appropriate to their needs. GOS ICH generates the funding for our research by setting out our proposals in high quality applications to public, charitable and industrial funding bodies and disseminates the results of our research by publication in the medical and scientific literature, to clinicians, policy makers and the wider public. The Institute offers world-class education and training across a wide range of teaching and life learning programmes which address the needs of students and professional groups who are interested in and undertaking work relevant to child health. GOS ICH holds an Athena SWAN Charter Gold Award.
As London's Global University, we know diversity fosters creativity and innovation, and we want our community to represent the diversity of the world's talent. We are committed to equality of opportunity, to being fair and inclusive, and to being a place where we all belong. We therefore particularly encourage applications from candidates who are likely to be underrepresented in UCL's workforce. These include people from Black, Asian and ethnic minority backgrounds; disabled people; LGBTQI+ people; and for our Grade 9 and 10 roles, women. You can
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