Research Fellow in Structural Biology (CryoEM)

Are you an ambitious researcher looking for your next challenge? Do you have an established background in cryoEM and want to help to develop new routes to combat amyloid diseases? Do you want to further your career in one of the UKs leading research intensive Universities?

We are looking for an outstanding research fellow to join our interdisciplinary team that is investigating how proteins aggregate into amyloid fibrils, and how fibrils with different structure perturb cellular function. This BIRAX-funded role is to use cryoEM, supported with other biochemical and biophysical analyses, to understand the structure of amyloid fibrils formed in vitro and purified from patient samples and to determine the activity of different fibril types in causing neuronal dysfunction. This will help to reveal the mechanisms by which disease-relevant mutations and post-translational modifications effect changes in amyloid aggregate formation and the consequences of aggregation on cellular function.

You will be based in the laboratories of Professors Sheena Radford and Neil Ranson, and work closely with other members of our amyloid team. The work will be carried out in collaboration with Professor Raz Jelinek (Ben Gurion University) who has recently shown an activity of amyloid fibrils in the degradation of neurotransmitters. You should have a PhD (or be close to completing one) in Structural Biology, Biochemistry, or a related discipline, and extensive experience of using cryoEM to solve questions about protein structure, assembly and biological mechanisms.