Research Associate

The Prywes Lab at the University of Cambridge Biochemistry department is seeking a postdoc with experience in protein engineering. Experience with high throughput sequencing, metabolic circuit manipulation, microbiology and in vitro enzymology is desirable.

The Prywes lab studies studies enzyme evolution, mechanism and engineering (visit our website, pryweslab.org). We have previously generated a map of the rubisco biochemical landscape (Prywes et al. Nature 2025). Current lab aims include expanding that landscape and studying enzyme mechanism through high-throughput data generation.

The project for this position will involve growth-coupled E. coli strains to study enzyme properties in high throughput. The project will involve Machine-Learning for protein design, mutant library generation and cloning, library selection by E. coli growth and high throughput sequencing and analysis. In vitro enzymology will also be required. The ideal candidate will possess expertise in two or more of these techniques and demonstrate a willingness to learn new methods and concepts. Moreover, a suitable candidate will have completed a PhD and demonstrated a high research impact and extensive experience. We are looking for individuals who can think independently and serve as a driving force for their research projects.

Fixed-term: The funds for this post are available for 18 months in the first instance.